Theoretical underpinning of the single-molecule-dilution (SMD) method of direct haplotype resolution.

In a recent paper we have shown that DNA haplotypes of multiply heterozygous individuals can be resolved directly by polymerase-chain-reaction (PCR) amplification of a single molecule of genomic template. Our method (the single-molecule-dilution [SMD] method) relies on the stochastic separation of m...

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Bibliographic Details
Main Authors: Stephens, J C, Rogers, J, Ruano, G
Format: Artigo
Language:Inglês
Published: 1990
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1683843/
https://ncbi.nlm.nih.gov/pubmed/2339707
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