Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules.

We have developed a reliable method for the direct resolution of haplotypes or linkage phase from individuals who are multiply heterozygous in a given genomic region. The method is based on single-molecule dilution (SMD) of genomic template and amplification via biphasic polymerase chain reaction (b...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ruano, G, Kidd, K K, Stephens, J C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54520/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1974719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.16.6296
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