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Stable expression of pertussis toxin in Bordetella bronchiseptica under the control of a tightly regulated promoter.

Pertussis toxin (PT) is an essential component of accellular vaccines against whooping cough. However, the industrial production of PT from Bordetella pertussis is impaired by slow growth and poor yields. To overcome these problems, we have constructed a minitransposon containing the tox operon unde...

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Udgivet i:Appl Environ Microbiol
Principais autores: Suarez, A, Staendner, L H, Rohde, M, Piatti, G, Timmis, K N, Guzmán, C A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC168309/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8979346/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.63.1.122-127.1997
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