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Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans.

The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (...

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Autors principals: Zhang, D, Hansen, E B, Deck, J, Heinze, T M, Sutherland, J B, Cerniglia, C E
Format: Artigo
Idioma:Inglês
Publicat: 1996
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC168147/
https://ncbi.nlm.nih.gov/pubmed/8795241
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