High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells

To test the ability of triple helix-forming oligonucleotides (TFOs) to promote recombination within chromosomal sites in mammalian cells, a mouse LTK(−) cell line was established carrying two mutant copies of the herpes simplex virus thymidine kinase (TK) gene as direct repeats in a single chromosom...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Luo, Zhongjun, Macris, Margaret A., Faruqi, A. Fawad, Glazer, Peter M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16811/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10900269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160004997
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