High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells
To test the ability of triple helix-forming oligonucleotides (TFOs) to promote recombination within chromosomal sites in mammalian cells, a mouse LTK(−) cell line was established carrying two mutant copies of the herpes simplex virus thymidine kinase (TK) gene as direct repeats in a single chromosom...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2000
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16811/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10900269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160004997 |
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