The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss and muscle wasting. In muscles of ALS patients, Nogo-A—a protein known to inhibit axon regeneration—is ectopically expressed at levels that correlate with the severity of the clinical symptoms. We n...

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Detalhes bibliográficos
Main Authors: Jokic, Natasa, Gonzalez de Aguilar, Jose-Luis, Dimou, Leda, Lin, Shuo, Fergani, Anissa, Ruegg, Markus A, Schwab, Martin E, Dupuis, Luc, Loeffler, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679784/
https://ncbi.nlm.nih.gov/pubmed/17039253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400826
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