Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients

OBJECTIVE: Data from mouse models of amyotrophic lateral sclerosis (ALS) suggest early morphological changes in neuromuscular junctions (NMJs), with loss of nerve–muscle contact. Overexpression of the neurite outgrowth inhibitor Nogo-A in muscle may play a role in this loss of endplate innervation....

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Bruneteau, Gaëlle, Bauché, Stéphanie, Gonzalez de Aguilar, Jose Luis, Brochier, Guy, Mandjee, Nathalie, Tanguy, Marie-Laure, Hussain, Ghulam, Behin, Anthony, Khiami, Frédéric, Sariali, Elhadi, Hell-Remy, Caroline, Salachas, François, Pradat, Pierre-François, Lacomblez, Lucette, Nicole, Sophie, Fontaine, Bertrand, Fardeau, Michel, Loeffler, Jean-Philippe, Meininger, Vincent, Fournier, Emmanuel, Koenig, Jeanine, Hantaï, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402082/
https://ncbi.nlm.nih.gov/pubmed/25909082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.179
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