FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells

The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes in the majority of common human cancers. The human Fhit protein undergoes phosphorylation on tyrosine residue 114 by Src and related kinases both in vitro and in vivo. Src is a key cytoplasmic tyrosine kinase downstream...

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Main Authors: Bianchi, Francesca, Magnifico, Alessandra, Olgiati, Clelia, Zanesi, Nicola, Pekarsky, Yuri, Tagliabue, Elda, Croce, Carlo Maria, Ménard, Sylvie, Campiglio, Manuela
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679754/
https://ncbi.nlm.nih.gov/pubmed/17142325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605821103
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