FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells

The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes in the majority of common human cancers. The human Fhit protein undergoes phosphorylation on tyrosine residue 114 by Src and related kinases both in vitro and in vivo. Src is a key cytoplasmic tyrosine kinase downstream...

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Bibliografiska uppgifter
Huvudupphovsmän: Bianchi, Francesca, Magnifico, Alessandra, Olgiati, Clelia, Zanesi, Nicola, Pekarsky, Yuri, Tagliabue, Elda, Croce, Carlo Maria, Ménard, Sylvie, Campiglio, Manuela
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679754/
https://ncbi.nlm.nih.gov/pubmed/17142325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605821103
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