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FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes in the majority of common human cancers. The human Fhit protein undergoes phosphorylation on tyrosine residue 114 by Src and related kinases both in vitro and in vivo. Src is a key cytoplasmic tyrosine kinase downstream...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679754/ https://ncbi.nlm.nih.gov/pubmed/17142325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605821103 |
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