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Regulation of Phosphorylation of Tau by Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase-3 at Substrate Level
Microtubule associated protein tau, which is expressed in six alternatively spliced molecular isoforms in human brain, is abnormally hyperphosphorylated in Alzheimer disease and related tauopathies. Here we show (i) that GSK-3α and neither GSK-3β nor cdk5 can phosphorylate tau at Ser262 and phosphor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679721/ https://ncbi.nlm.nih.gov/pubmed/17045592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.09.060 |
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