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Regulation of Phosphorylation of Tau by Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase-3 at Substrate Level

Microtubule associated protein tau, which is expressed in six alternatively spliced molecular isoforms in human brain, is abnormally hyperphosphorylated in Alzheimer disease and related tauopathies. Here we show (i) that GSK-3α and neither GSK-3β nor cdk5 can phosphorylate tau at Ser262 and phosphor...

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Detaylı Bibliyografya
Asıl Yazarlar: Sengupta, Amitabha, Novak, Michal, Grundke-Iqbal, Inge, Iqbal, Khalid
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679721/
https://ncbi.nlm.nih.gov/pubmed/17045592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.09.060
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