Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice

Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic β cells. In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein ki...

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Hlavní autoři: Choi, Young Hun, Park, Sunhee, Hockman, Steven, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Haluzik, Martin, Gavrilova, Oksana, Ahmad, Faiyaz, Pepin, Laurent, Napolitano, Maria, Taira, Masato, Sundler, Frank, Stenson Holst, Lena, Degerman, Eva, Manganiello, Vincent C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2006
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1678809/
https://ncbi.nlm.nih.gov/pubmed/17143332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24867
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