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A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development

Nonsense mutations are usually assumed to affect protein function by generating truncated protein products. Nonetheless, it is now clear that these mutations affect not just protein synthesis but also messenger RNA stability. The surveillance mechanism responsible for the detection and degradation o...

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Detalles Bibliográficos
Main Authors: Alonso, Claudio R., Akam, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC167643/
https://ncbi.nlm.nih.gov/pubmed/12853602
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