Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3′-UTRs

Alternative polyadenylation leads to mRNAs with variable 3′ ends. Since a 3′-untranslated region (3′-UTR) often contains cis elements that impact stability or localization of mRNA or translation, selection of poly(A) sites in a 3′-UTR is regulated in mammalian cells. However, the molecular basis for...

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Hlavní autoři: Kubo, Tomohiro, Wada, Tadashi, Yamaguchi, Yuki, Shimizu, Akira, Handa, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2006
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1669743/
https://ncbi.nlm.nih.gov/pubmed/17098938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl794
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