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Effects of narcotic analgesics on the uptake and release of 5-hydroxytryptamine in rat synaptosomal preparations

1 The effects of various narcotic analgesics on the uptake and release of labelled 5-hydroxytryptamine (5-HT) in brain and spinal cord synaptosomes were investigated. 2 Methadone was most active in inhibiting 5-HT uptake (IC(50) 2.5 × 10(-7) M). Levorphanol also inhibited 5-HT uptake to a large exte...

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Main Authors: Mennini, Tiziana, Pataccini, R., Samanin, R.
格式: Artigo
語言:Inglês
出版: 1978
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1668261/
https://ncbi.nlm.nih.gov/pubmed/29686
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