Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor α (TNF-α) in obesity is involved in functional brown fat atrophy, we have studied genetically obese (ob/ob) mice with targeted null mutations in the...

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Detaylı Bibliyografya
Asıl Yazarlar: Nisoli, Enzo, Briscini, Luca, Giordano, Antonio, Tonello, Cristina, Wiesbrock, Sarah M., Uysal, K. Teoman, Cinti, Saverio, Carruba, Michele O., Hotamisligil, Gökhan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2000
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC16665/
https://ncbi.nlm.nih.gov/pubmed/10884431
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