Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor α (TNF-α) in obesity is involved in functional brown fat atrophy, we have studied genetically obese (ob/ob) mice with targeted null mutations in the...

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Main Authors: Nisoli, Enzo, Briscini, Luca, Giordano, Antonio, Tonello, Cristina, Wiesbrock, Sarah M., Uysal, K. Teoman, Cinti, Saverio, Carruba, Michele O., Hotamisligil, Gökhan S.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC16665/
https://ncbi.nlm.nih.gov/pubmed/10884431
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