Mechanism of action of a pestivirus antiviral compound

We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine viral diarrhea virus (BVDV) in cell culture at a 50% inhibitory concentration of approximately 20 nM. VP32947 inhibits both cytopathic and noncyt...

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Autori principali: Baginski, Scott G., Pevear, Daniel C., Seipel, Marty, Sun, Siu Chi Chang, Benetatos, Christopher A., Chunduru, Srinivas K., Rice, Charles M., Collett, Marc S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC16656/
https://ncbi.nlm.nih.gov/pubmed/10869440
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