Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation

An increase in stimulation frequency causes an acceleration of myocardial relaxation (FDAR). Several mechanisms have been postulated to explain this effect, among which is the Ca(2+)–calmodulin-dependent protein kinase (CaMKII)-dependent phosphorylation of the Thr(17) site of phospholamban (PLN). To...

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מידע ביבליוגרפי
Main Authors: Valverde, Carlos A, Mundiña-Weilenmann, Cecilia, Said, Matilde, Ferrero, Paola, Vittone, Leticia, Salas, Margarita, Palomeque, Julieta, Petroff, Martín Vila, Mattiazzi, Alicia
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Science Inc 2005
נושאים:
Tissue, System and Organ Physiology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665530/
https://ncbi.nlm.nih.gov/pubmed/15528241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.075432
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