Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation

An increase in stimulation frequency causes an acceleration of myocardial relaxation (FDAR). Several mechanisms have been postulated to explain this effect, among which is the Ca(2+)–calmodulin-dependent protein kinase (CaMKII)-dependent phosphorylation of the Thr(17) site of phospholamban (PLN). To...

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Détails bibliographiques
Auteurs principaux: Valverde, Carlos A, Mundiña-Weilenmann, Cecilia, Said, Matilde, Ferrero, Paola, Vittone, Leticia, Salas, Margarita, Palomeque, Julieta, Petroff, Martín Vila, Mattiazzi, Alicia
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2005
Sujets:
Tissue, System and Organ Physiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665530/
https://ncbi.nlm.nih.gov/pubmed/15528241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.075432
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