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Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1–MAGE-A1 from a nonimmunized phage-Fab library

Antitumor antibodies with the same specificity as cytotoxic T lymphocytes that recognize antigenic peptides encoded by tumor-associated genes and presented by MHC class I molecules would be valuable tools to analyze the antigenicity or target tumor cells in vivo. To obtain a human antibody directed...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chames, Patrick, Hufton, Simon E., Coulie, Pierre G., Uchanska-Ziegler, Barbara, Hoogenboom, Hennie R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16654/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884427/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7969
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