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Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1–MAGE-A1 from a nonimmunized phage-Fab library

Antitumor antibodies with the same specificity as cytotoxic T lymphocytes that recognize antigenic peptides encoded by tumor-associated genes and presented by MHC class I molecules would be valuable tools to analyze the antigenicity or target tumor cells in vivo. To obtain a human antibody directed...

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Detalhes bibliográficos
Main Authors: Chames, Patrick, Hufton, Simon E., Coulie, Pierre G., Uchanska-Ziegler, Barbara, Hoogenboom, Hennie R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16654/
https://ncbi.nlm.nih.gov/pubmed/10884427
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