Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers

Loss of hypocretin cells or mutation of hypocretin receptors causes narcolepsy. In canine genetic narcolepsy, produced by a mutation of the Hcrtr2 gene, symptoms develop postnatally with symptom onset at 4 weeks of age and maximal symptom severity by 10–32 weeks of age. Canine narcolepsy can readily...

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Bibliographic Details
Main Authors: John, Joshi, Wu, Ming-Fung, Maidment, Nigel T, Lam, Hoa A, Boehmer, Lisa N, Patton, Melanie, Siegel, Jerome M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665256/
https://ncbi.nlm.nih.gov/pubmed/15308685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.070573
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