Role of the Hypocretin (Orexin) Receptor 2 (Hcrt-r2) in the Regulation of Hypocretin Level and Cataplexy

Hypocretin receptor-2 (Hcrt-r2)-mutated dogs exhibit all the major symptoms of human narcolepsy and respond to drugs that increase or decrease cataplexy as do narcoleptic humans; yet, unlike narcoleptic humans, the narcoleptic dogs have normal hypocretin levels. We find that drugs that reduce or inc...

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Detalhes bibliográficos
Main Authors: Wu, Ming-Fung, Nienhuis, Robert, Maidment, Nigel, Lam, Hoa A., Siegel, Jerome M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097029/
https://ncbi.nlm.nih.gov/pubmed/21525270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0365-11.2011
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