Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels

Long-term potentiation (LTP) in the hippocampal CA1 region requires the activation of NMDA receptors (NMDARs). NMDAR activation in turn requires membrane depolarization as well as the binding of glutamate and its coagonist glycine. Previous pharmacological studies suggest that the glycine transporte...

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Detalhes bibliográficos
Main Authors: Martina, Marzia, Gorfinkel, Yelena, Halman, Samantha, Lowe, John A, Periyalwar, Pranav, Schmidt, Christopher J, Bergeron, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665089/
https://ncbi.nlm.nih.gov/pubmed/15064326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.063321
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