West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H

The complement system, by virtue of its dual effector and priming functions, is a major host defense against pathogens. Flavivirus nonstructural protein (NS)-1 has been speculated to have immune evasion activity, because it is a secreted glycoprotein, binds back to cell surfaces, and accumulates to...

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Main Authors: Chung, Kyung Min, Liszewski, M. Kathryn, Nybakken, Grant, Davis, Alan E., Townsend, R. Reid, Fremont, Daved H., Atkinson, John P., Diamond, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664712/
https://ncbi.nlm.nih.gov/pubmed/17132743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605668103
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