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Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single m...

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Main Authors: Dressman, Devin, Yan, Hai, Traverso, Giovanni, Kinzler, Kenneth W., Vogelstein, Bert
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC166396/
https://ncbi.nlm.nih.gov/pubmed/12857956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133470100
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