Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

β-TrCP1 (also known as Fbw1a or FWD1) is the F-box protein component of an Skp1/Cul1/F-box (SCF)-type ubiquitin ligase complex. Although biochemical studies have suggested that β-TrCP1 targets inhibitory subunit of NF-κB(IκB) proteins and β-catenin for ubiquitylation, the physiological role of β-TrC...

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Bibliographische Detailangaben
Hauptverfasser: Nakayama, Keiko, Hatakeyama, Shigetsugu, Maruyama, Shun-ichiro, Kikuchi, Akira, Onoé, Kazunori, Good, Robert A., Nakayama, Keiichi I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166385/
https://ncbi.nlm.nih.gov/pubmed/12843402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133216100
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