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Natural selection of more designable folds: A mechanism for thermophilic adaptation

An open question of great interest in biophysics is whether variations in structure cause protein folds to differ in the number of amino acid sequences that can fold to them stably, i.e., in their designability. Recently, we have shown that a novel quantitative measure of a fold's tertiary topo...

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Библиографические подробности
Главные авторы: England, Jeremy L., Shakhnovich, Boris E., Shakhnovich, Eugene I.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC166380/
https://ncbi.nlm.nih.gov/pubmed/12843403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530713100
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