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Natural selection of more designable folds: A mechanism for thermophilic adaptation

An open question of great interest in biophysics is whether variations in structure cause protein folds to differ in the number of amino acid sequences that can fold to them stably, i.e., in their designability. Recently, we have shown that a novel quantitative measure of a fold's tertiary topo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: England, Jeremy L., Shakhnovich, Boris E., Shakhnovich, Eugene I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166380/
https://ncbi.nlm.nih.gov/pubmed/12843403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530713100
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