Modeling the fission yeast cell cycle: Quantized cycle times in wee1(−) cdc25Δ mutant cells

A detailed mathematical model for the fission yeast mitotic cycle is developed based on positive and negative feedback loops by which Cdc13/Cdc2 kinase activates and inactivates itself. Positive feedbacks are created by Cdc13/Cdc2-dependent phosphorylation of specific substrates: inactivating its ne...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Sveiczer, Akos, Csikasz-Nagy, Attila, Gyorffy, Bela, Tyson, John J., Novak, Bela
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2000
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16636/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7865
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