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Modeling the fission yeast cell cycle: Quantized cycle times in wee1(−) cdc25Δ mutant cells

A detailed mathematical model for the fission yeast mitotic cycle is developed based on positive and negative feedback loops by which Cdc13/Cdc2 kinase activates and inactivates itself. Positive feedbacks are created by Cdc13/Cdc2-dependent phosphorylation of specific substrates: inactivating its ne...

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Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Sveiczer, Akos, Csikasz-Nagy, Attila, Gyorffy, Bela, Tyson, John J., Novak, Bela
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2000
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16636/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884416/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7865
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