Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

Sphingosine and sphingosine-1-phosphate (SPP) are interconvertible sphingolipid metabolites with opposing effects on cell growth and apoptosis. Based on sequence homology with LBP1, a lipid phosphohydrolase that regulates the levels of phosphorylated sphingoid bases in yeast, we report here the clon...

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Main Authors: Mandala, Suzanne M., Thornton, Rosemary, Galve-Roperh, Ismael, Poulton, Samantha, Peterson, Courtney, Olivera, Ana, Bergstrom, James, Kurtz, Myra B., Spiegel, Sarah
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC16635/
https://ncbi.nlm.nih.gov/pubmed/10859351
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