Pex13 Inactivation in the Mouse Disrupts Peroxisome Biogenesis and Leads to a Zellweger Syndrome Phenotype

Zellweger syndrome is the archetypical peroxisome biogenesis disorder and is characterized by defective import of proteins into the peroxisome, leading to peroxisomal metabolic dysfunction and widespread tissue pathology. In humans, mutations in the PEX13 gene, which encodes a peroxisomal membrane p...

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הוצא לאור ב:	Mol Cell Biol
Principais autores:	Maxwell, Megan, Bjorkman, Jonas, Nguyen, Tam, Sharp, Peter, Finnie, John, Paterson, Carol, Tonks, Ian, Paton, Barbara C., Kay, Graham F., Crane, Denis I.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis 2003
נושאים:	Mammalian Genetic Models with Minimal or Complex Phenotypes
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.16.5947-5957.2003
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