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A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

Smad proteins are intracellular mediators of transforming growth factor β (TGF-β) and related cytokines and undergo ligand-induced nuclear translocation. Here we describe the identification of a nuclear localization signal (NLS) in the N-terminal region of Smad 3, the major Smad protein involved in...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Xiao, Zhan, Liu, Xuedong, Henis, Yoav I., Lodish, Harvey F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16634/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884415/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7853
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