Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

The DNA-dependent protein kinase (DNA-PK) plays an essential role in nonhomologous DNA end joining (NHEJ) by initially recognizing and binding to DNA breaks. We have shown that in vitro, purified DNA-PK undergoes autophosphorylation, resulting in loss of activity and disassembly of the kinase comple...

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Autores principales: Ding, Qi, Reddy, Yeturu V. R., Wang, Wei, Woods, Timothy, Douglas, Pauline, Ramsden, Dale A., Lees-Miller, Susan P., Meek, Katheryn
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
DNA Dynamics and Chromosome Structure
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC166339/
https://ncbi.nlm.nih.gov/pubmed/12897153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5836-5848.2003
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