A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor

LDL receptor-related protein 6 (LRP6) is a Wnt coreceptor in the canonical signaling pathway, which plays essential roles in embryonic development. We demonstrate here that wild-type LRP6 forms an inactive dimer through interactions mediated by epidermal growth factor repeat regions within the extra...

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Bibliographic Details
Main Authors: Liu, Guizhong, Bafico, Anna, Harris, Violaine K., Aaronson, Stuart A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166321/
https://ncbi.nlm.nih.gov/pubmed/12897152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5825-5835.2003
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