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A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor
LDL receptor-related protein 6 (LRP6) is a Wnt coreceptor in the canonical signaling pathway, which plays essential roles in embryonic development. We demonstrate here that wild-type LRP6 forms an inactive dimer through interactions mediated by epidermal growth factor repeat regions within the extra...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC166321/ https://ncbi.nlm.nih.gov/pubmed/12897152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5825-5835.2003 |
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