Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells

Loss of p53 sensitizes to antimicrotubule agents in human tumor cells, but little is known about its role during mitosis. We have identified the Polo-like kinase family member serum inducible kinase (Snk/Plk2) as a novel p53 target gene. Snk/Plk2 mutagenesis demonstrated that its kinase activity is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Burns, Timothy F., Fei, Peiwen, Scata, Kimberly A., Dicker, David T., El-Deiry, Wafik S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2003
Pynciau:
Cell Growth and Development
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC166320/
https://ncbi.nlm.nih.gov/pubmed/12897130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5556-5571.2003
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