The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1(+/+)) littermates, mice lacking CB1 (CB1...

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Main Authors: Cota, Daniela, Marsicano, Giovanni, Tschöp, Matthias, Grübler, Yvonne, Flachskamm, Cornelia, Schubert, Mirjam, Auer, Dorothee, Yassouridis, Alexander, Thöne-Reineke, Christa, Ortmann, Sylvia, Tomassoni, Federica, Cervino, Cristina, Nisoli, Enzo, Linthorst, Astrid C.E., Pasquali, Renato, Lutz, Beat, Stalla, Günter K., Pagotto, Uberto
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC166293/
https://ncbi.nlm.nih.gov/pubmed/12897210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317725
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