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The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase

To reveal the structural principles determining substrate specificity of 4-coumarate:CoA ligase (4CL), the crystal structure of the phenylalanine activation domain of gramicidin S synthetase was used as a template for homology modeling. According to our model, 12 amino acid residues lining the Arabi...

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Autors principals: Schneider, Katja, Hövel, Klaus, Witzel, Kilian, Hamberger, Björn, Schomburg, Dietmar, Kombrink, Erich, Stuible, Hans-Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC166275/
https://ncbi.nlm.nih.gov/pubmed/12819348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1430550100
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