Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

Loss of the renal endosome-associated chloride channel, ClC-5, in Dent's disease and knockout (KO) mice strongly inhibits endocytosis of filtered proteins by kidney proximal tubular cells (PTC). The underlying mechanism remains unknown. We therefore tested whether this endocytic failure could p...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Christensen, Erik I., Devuyst, Olivier, Dom, Geneviève, Nielsen, Rikke, Van Der Smissen, Patrick, Verroust, Pierre, Leruth, Michèle, Guggino, William B., Courtoy, Pierre J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC166253/
https://ncbi.nlm.nih.gov/pubmed/12815097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432873100
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller