Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

Loss of the renal endosome-associated chloride channel, ClC-5, in Dent's disease and knockout (KO) mice strongly inhibits endocytosis of filtered proteins by kidney proximal tubular cells (PTC). The underlying mechanism remains unknown. We therefore tested whether this endocytic failure could p...

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Bibliografische gegevens
Hoofdauteurs: Christensen, Erik I., Devuyst, Olivier, Dom, Geneviève, Nielsen, Rikke, Van Der Smissen, Patrick, Verroust, Pierre, Leruth, Michèle, Guggino, William B., Courtoy, Pierre J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2003
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166253/
https://ncbi.nlm.nih.gov/pubmed/12815097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432873100
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