Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

Loss of the renal endosome-associated chloride channel, ClC-5, in Dent's disease and knockout (KO) mice strongly inhibits endocytosis of filtered proteins by kidney proximal tubular cells (PTC). The underlying mechanism remains unknown. We therefore tested whether this endocytic failure could p...

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Autores principales: Christensen, Erik I., Devuyst, Olivier, Dom, Geneviève, Nielsen, Rikke, Van Der Smissen, Patrick, Verroust, Pierre, Leruth, Michèle, Guggino, William B., Courtoy, Pierre J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC166253/
https://ncbi.nlm.nih.gov/pubmed/12815097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432873100
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