TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

Tumor necrosis factor α (TNF-α) is an important mediator of programmed cell death, and TNF-α blockade significantly improves disease severity in several inflammatory conditions, including Crohn's disease (CD), one of the idiopathic inflammatory bowel diseases. However, the precise mechanism(s)...

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Главные авторы: Marini, Marco, Bamias, Giorgos, Rivera-Nieves, Jesús, Moskaluk, Christopher A., Hoang, Sharon B., Ross, William G., Pizarro, Theresa T., Cominelli, Fabio
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC166235/
https://ncbi.nlm.nih.gov/pubmed/12832622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432897100
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