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Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

The outer leaflet of the outer membrane of the Gram-negative bacterium serves as a permeability barrier and is composed of lipopolysaccharide, also known as endotoxin. The membrane anchor of lipopolysaccharide is lipid A, the biosynthesis of which is essential for cell viability. The first committed...

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Autori principali: Whittington, Douglas A., Rusche, Kristin M., Shin, Hyunshun, Fierke, Carol A., Christianson, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC166197/
https://ncbi.nlm.nih.gov/pubmed/12819349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432990100
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