SPARC-Induced Migration of Glioblastoma Cell Lines via uPA-uPAR Signaling and Activation of Small GTPase RhoA

Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas where it promotes invasion and delays tumor growth, both in vitro and in vivo. SPARC, which interacts at the cell surface, has an impact on intracellular signaling and downstream gene expression changes, which...

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Hlavní autoři: Kunigal, Sateesh, Gondi, Christopher, Gujrati, Meena, Lakka, Sajani S., Dinh, Dzung H., Olivero, William C., Rao, Jasti S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1661847/
https://ncbi.nlm.nih.gov/pubmed/17088972
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