Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these...

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Bibliographic Details
Main Authors: Biagini, Giancarlo A., Richier, Eric, Bray, Patrick G., Calas, Michèle, Vial, Henri, Ward, Stephen A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166076/
https://ncbi.nlm.nih.gov/pubmed/12878523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2584-2589.2003
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