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Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Biagini, Giancarlo A., Richier, Eric, Bray, Patrick G., Calas, Michèle, Vial, Henri, Ward, Stephen A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC166076/
https://ncbi.nlm.nih.gov/pubmed/12878523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2584-2589.2003
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