Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Biagini, Giancarlo A., Richier, Eric, Bray, Patrick G., Calas, Michèle, Vial, Henri, Ward, Stephen A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2003
Предметы:	Mechanisms of Action: Physiological Effects
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2584-2589.2003
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