Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums
Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these...
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| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2584-2589.2003 |
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